Figure 1
Dose-dependent effects of PQ on survival of mice and identification of a sublethal dose of PQ. Survival of mice indicates number of animals alive after PQ treatment. Intraperitoneal injection of PQ with various doses (5, 10, 20, 40, 80 mg/kg b.w.) caused death of animals at doses of 20, 40 and 80 mg/kg b.w. of PQ. Animals treated with PQ at doses of 5 and 10 mg/kg b.w. remained alive during the entire treatment period, and were sacrificed after the final treatment as described in Methods. Animals treated with 80 mg PQ/kg b.w. died within 8 hours of the 1st dose. Experiments were performed with 10 animals in each group. Error bars represent animals that were alive on different days after treatment of PQ with doses of 20 mg/kg b.w. and 40 mg/kg b.w.