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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size

Figure 1

Systemic inflammatory challenges compromise survival after experimental stroke. A. Measurement of Ova-specific IgGE in plasma with ELISA confirms proper sensitization to antigen in Ova injected mice without (Ova) and with (Ova+A) anaplylaxis. B. Plasma IL-1β levels were determined with ELISA after 60 min MCAo and 24 h reperfusion. C. Percentage values show the average survival rate of mice at 24 h reperfusion after various challenges and MCAo or sham surgery. Anaphylaxis induced by intraperitoneal (i.p.), intravenous (i.v.) Ova administration in sensitized mice. Systemic inflammation induced by i.p. LPS injection 3 hours prior to MCAo profoundly increase mortality within 24 hours (n = 4-11/group). One-way ANOVA followed by Bonferroni's comparison (*P < 0.05 vs Control).

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Journal of Neuroinflammation

ISSN: 1742-2094