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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size

Figure 6

Hypothermia reduces brain injury but does not prevent increased brain oedema formation after anaphylaxis. Hypothermia combined with 60 minutes of MCAo results in profound protection against ischaemia in all animal groups compared to normothermia (P < 0.001, see Figure 2). Body temperature was reduced to 33°C by spontaneous heat loss during surgery and was maintained between 33-34°C during occlusion. A. The volume of the ischaemic damage was measured on cresyl violet (Nissl) stained serial brain sections (B). C. Anaphylaxis significantly increases brain oedema after MCAo and 24 hours of reperfusion compared to Ova sensitization (P < 0.05, One-way ANOVA, Bonferroni's post-hoc comparison) in hypothermic mice with 60 minutes of MCAo. Data are representative of 5 mice/group. n.s.- not significant.

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