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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Neuropeptide Y inhibits interleukin-1β-induced phagocytosis by microglial cells

Figure 4

NPY inhibits LPS-induced actin cytoskeleton reorganization. Representative confocal photomicrographs were taken to assess the role of LPS on rearrangement of the actin cytoskeleton. Microglial cells treated with LPS (100 ng/ml) showed significant membrane ruffling, while NPY (1 μM) reduced this effect. Moreover, microglial cells treated with LPS (100 ng/ml), in the presence of SB239063, showed a cytoskeleton rearrangement similar to that of untreated cells. Cells were stained for actin (in red), CD11b (in green) and Hoechst 33342 (nuclei in blue). Scale bar 10 μm.

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