The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment

Table 1 Clinical characteristics and correlations with cognitive impairment (n = 41)

	MEAN ± SD OR %	RANGE	r- OR F* VALUE	P-VALUE^†
Age	72.3 ± 12.2 years	39-91 years	-0.27	0.08
Gender	53.7% male		1.83	0.18
MMSE	25.6 ± 4.1	13-30	-	-
NIHSS	7.27 ± 5.55	0-21	-0.08	0.63
CES-D	13.8 ± 12.8	0-48	-0.09	0.59
History of Depression	7.3%		0.35	0.56
Living Alone	24.4%		0.06	0.81
Level of Education > high school	46.3%		6.64	0.01
Time Since Stroke	9.17 ± 5.03 days	4-26 days	-0.34	0.03
Cerebrovascular Risk Factors
Hypertension	85.4%		4.53	0.04
Diabetes	26.8%		0.21	0.65
Hyperlipidemia	34.1%		0.41	0.52
Obesity (BMI ≥ 30kg/m²)	31.7%		2.17	0.15
Smoking	22.0%		0.10	0.75
Total number risk factors	2.15 ± 1.28	0-5	-0.21	0.19
Lesion Volume (cm³)	31.72 ± 55.09	0.250 -287.58	-0.05	0.76
K/T ratio ^‡	67.40 ± 42.46	14.04-203.75	-0.33	0.04

Abbreviations: MMSE, Mini-Mental State Examination; NIHSS, National Institutes of Health Stroke Scale; CES-D, Center for Epidemiological Studies-Depression Scale; BMI, body mass index; K/T ratio, Kynurenine/Tryptophan ratio
*r or F values and their corresponding ^†p-values reflect the results of bivariate Pearson correlations with sMMSE scores for continuous variables and ANOVA between sMMSE scores -for categorical variables;^‡ values reflect the mean ± SD of the detectable samples in each group.

ISSN: 1742-2094