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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice

Figure 2

Leukocyte counts in sections of the injury site of MT-I/II -/- mice (white bars) and wild type mice (grey bars) standardised to injury area. Neutrophil numbers (A) were determined by NIMP-14 immunoreactivity. Microglial and monocyte derived macrophages numbers (B) were determined by Iba1 immunoreactivity. T cell numbers (C) were determined by CD3 immunoreactivity. Lower case letters indicate significance determined by Tukey's B post-hoc test. Time-points sharing letters indicates lack of statistically significant difference. n = 5-7, error bars = SEM. Immunohistochemistry within the injury site is shown for neutrophils at 1 DPI with nuclear-fast red counter stain (D), macrophages at 7 DPI with nuclear-fast red counter stain (E) and T cells at 7 DPI without counterstain (D). Arrows indicate examples of positively stained cells, Scale bars = 100 μm.

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