Figure 2
From: Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors
IL-1β induces increases in mRNAs encoding ApoE, βAPP, and the proinflammatory factors IL-1β, ICE, IL-1α, and TNF. RNA was extracted from the left cerebral cortex of unoperated rats (Control), rats implanted in the right cerebrum with a pellet containing vehicle alone (Sham), and rats implanted in the right cerebrum with a slow-release pellet containing 100 ng IL-1β (IL-1β Pellet); A: semi-quantitative RT-PCR was performed on the RNA. B: Results quantified by densitometry showed significant differences in mRNA levels from brains with IL-1β pellets compared to those with sham pellets, or from those serving as controls; p≤0.05 for each gene product.