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Figure 2 | Journal of Neuroinflammation

Figure 2

From: TLR3 signaling is either protective or pathogenic for the development of Theiler's virus-induced demyelinating disease depending on the time of viral infection

Figure 2

The course of TMEV-induced demyelinating disease development and viral persistence levels in NLM and TLR3KO-SJL mice. (A) Frequency and severity of demyelinating disease in NLM (n = 10) and TLR3KO-SJL (n = 10) were monitored for 80 days after TMEV infection. (B) Viral persistence levels in the brain (BR) and spinal cord (SC) of infected mice at 7, 21 and 50 dpi (DPI) were determined by plaque assay. Data represent values from a representative experiment from three independent experiments conducted with CNS pools of three mice per group. Statistically significant differences were indicated with asterisks (**, P < 0.01; ***, P < 0.001).

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