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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide

Figure 1

IGF-I does not affect sickness, but prevents the development of depression-like behavior induced by LPS. Mice were treated with vehicle or IGF-I (1 μg i.c.v.) followed 30 min later by vehicle or LPS (330 μg/kg body weight i.p.). Sickness was assessed as changes in body weight (A) and food intake (B), while sickness behavior was assessed as change in time spent investigating a novel juvenile (C). Depression-like behavior was quantified as the time of immobility during the FST, 9 h after treatment with LPS (D). n = 17-21 per treatment.

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