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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide

Figure 2

IGF-I does not affect sickness, but relieves depression-like behavior induced by LPS. Mice were treated with vehicle or LPS (830 μg/kg body weight i.p.) followed 24 h later by vehicle or IGF-I (1 μg i.c.v.). Sickness was assessed as changes in body weight (A) and food intake (B) while sickness behavior was assessed as change in general activity, 27 h after treatment with LPS (C). Depression-like behavior was quantified as the time of immobility during the FST, 30 h after treatment with LPS (D). n = 6.

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