Upregulation of IRF7 mRNA in CNS. A) Increased IRF7 gene expression correlated with clinical score. Values on Y axis are levels of IRF7 mRNA normalized to 18S rRNA expression. Values on the × axis show clinical score. B) Increased IRF7 gene expression by CD45dimCD11b+ microglia at peak disease was not statistically significant different from levels in CNS-infiltrating CD45highCD11b+ myeloid cells. ND: not detected; UNM: unmanipulated WT B6 mice.