Skip to main content


Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Figure 4 | Journal of Neuroinflammation

Figure 4

From: Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders

Figure 4

Scanning electron microscopy of serum AQP4-IgG mediated complement activation. Following incubation of AQP4 transfected HEK-293A cells with an NMO serum (AQP4-IgG titer: 1:10,240) and either active or inactive complement, the cells were investigated via scanning electron microscopy (1,000 × magnification). NMO serum supplemented with active complement resulted in increased apoptosis (shown by the detached cells, left panel). In contrast, the cell layer of NMO serum supplemented with inactive complement remained largely preserved (right panel). Images are representative of similar observations in independent complement activation assays.

Back to article page