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Table 2 Clinical characteristics of high-titer MOG-IgG seropositive patients with NMO (n = 3), HR-NMO (n = 7) and CIS (n = 2)

From: Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders

No./Sex/Age (y) Diagnosis MOG-IgG titer AQP4-IgG titer relapses ON myelitis LETM Cerebral MRI lesions MOG -TCC
1/F/2 NMO 1:2,560 negative 2 yes yes yes no pos
2/F/39 NMO 1:160 1:1,280 4 yes yes yes no n.a
3/M/56 NMO 1:2,560 negative 2 yes yes yes n.a pos
4/F/28 HR-NMO (rON) 1:5,120 negative 2 yes no no no pos
5/M/13 HR-NMO (rON) 1:5,120 negative 3 yes no no no pos
6/F/48 HR-NMO (rON) 1:2,560 negative 16 yes no no no pos
7/F/46 HR-NMO (rON) 1:640 negative 3 yes no no no neg
8/M/32* HR-NMO (rON) 1:640 negative 11 yes no no no neg
9/F/43 HR-NMO (LETM) 1:2,560 negative 1 no yes yes no pos
10/F/49* HR-NMO (LETM) 1:640 negative 1 no yes yes no pos
11/F/5 CIS (ON) 1:5,120 negative 1 yes no no no pos
12/M/13 CIS (ON) 1:640 negative 1 yes no no no neg
  1. Abbreviations: No. = patient number, F = female, M = male, y = years, MRI = magnetic resonance image, NMO = Neuromyelitis optica, HR-NMO = High-risk NMO, rON = recurrent optic neuritis, ON = optic neuritis, LETM = longitudinally extensive transverse myelitis, CIS = clinically isolated syndrome, MOG-TCC = MOG-IgG dependent terminal complement complex, n.a = not available. * paired serum and CSF samples were available from patient 8 and 10. The corresponding CSF was found to be negative for AQP4-IgG as well as for MOG-IgG (CSF was analyzed undiluted and diluted 1:2 as previously described [48]).