Figure 10

Schematic representation of the proposed molecular events that are affected by Ad-IRF3 in microglia. Ad-IRF3, through suppression of "M1-like" gene expression and over-expression of "M2-like" gene (IFNβ, IL-10 and IL-1ra) expression in microglia, can suppress proinflammatory cytokine cascades that are implicated in neurodegeneration. pAkt plays a major role in regulating microglial inflammatory gene expression. In Ad-IRF3-transduced microglia, a positive feedback mechanism between pAkt and pIRF3 could induce a state that is dominated by the "M2-like" cytokines. See text for details.