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Table 1 Microarray studies of microglia transduced with Ad-IRF3 or Ad-β-gal and stimulated with poly IC (PIC):

From: Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway

Gene

Ratio

(IRF3/β-gal)

Difference in expression

(IRF3 minus β-gal)

IFNB(IFNβ)

61.0

3863

IRF7

2.3

702

IL-1A (IL-1α)

0.22

-1413

IL-1RN (IL-1ra)

2.3

10836

IL-27

7.2

1291

IL-29 (IFN lambda)

75.0

231

IL-10RA (IL-10Rα)

3.3

954

IL-23 (p19)

0.47

-372

TLR7

2.2

813

  1. Human fetal microglia were transduced with adenovirus (Ad-IRF3 or Ad-β-gal) and further treated with the TLR3 ligand PIC for 16 h. Microarray was performed using the Illumina platform.