Figure 4

IGF-I decreases the inflammatory response of astrocytes exposed to LPS. mRNA levels of IL6 (A,B), IL-1β (C,D), TNF-α (E,F) and TLR4 (G,H) in astrocytes 24 h (A,C,E,G) or 72 h (B,D,F,H) after the addition of IGF-I (50 or 100 nM) or vehicle only and treated for the last 5 h with LPS. Data are presented as mean ± SEM and are expressed as percentage of control (vehicle + LPS) values. *,***, Significant differences (* P < 0.05; ***P < 0.001) in comparison to the values of cultures treated with vehicle + LPS.