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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Selective adenosine A2Areceptor agonists and antagonists protect against spinal cord injury through peripheral and central effects

Figure 1

Effects of systemic SCH58261 treatment on histological alterations and on hind limb motor disturbance after SCI. Twenty-four hours after trauma, significant damage to the SC of untreated SCI-operated mice in the perilesional area was assessed by the presence of alterations of white matter (b). It is noteworthy that significant protection from the SCI was observed in tissue collected from SCH58261-treated SCI-injured mice (c). No significant alterations were observed in sections obtained in sham groups (a). Myelin structure was observed by Luxol fast blue staining as well by Weigert's and Oil red O staining. Twenty-four hours after injury in SCI-operated mice (e, h respectively) a significant loss of myelin was observed. In contrast, myelin degradation was attenuated (f, i respectively) in SCH58261-treated mice. No significant alterations were observed in sections obtained in sham groups (d, g respectively). This figure is representative of at least 3 experiments performed on different experimental days. The histological score (l) was evaluated by an independent observer. ND: not detectable. One-way ANOVA: *°P < 0.01 vs sham group and SCI+vehicle, respectively. The degree of motor disturbance was assessed every day until 10 days after SCI by BMS motor score (m). Systemic administration of SCH58261 reduced the motor disturbance starting from the fourth day after SCI (m). Values are shown as mean ± S.E., with 10 mice in each group. One-way ANOVA: *P < 0.01 vs SCI+vehicle.

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