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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Selective adenosine A2Areceptor agonists and antagonists protect against spinal cord injury through peripheral and central effects

Figure 2

Effects of systemic SCH58261-administration on inflammation parameters. A substantial increase in TNF-α (2b), Fas-L (2e) and PAR (2h) expression was found in SC tissue collected from SCI+vehicle-treated mice 24 hours after SCI, in comparison with sham-operated mice (2a, d, g respectively). TNF-α (2c), Fas-L (2f) and PAR (2i) levels were attenuated in the SCI+SCH58261 group in comparison to SCI+vehicle animals. Sections of SC from sham vehicle-treated mice did not stain for Bax (2l) whereas SC sections obtained from SCI mice exhibited positive staining (2m). SCH58261 reduced the degree of staining for Bax (2n). Spinal cord sections from sham vehicle-treated mice demonstrated Bcl-2 positive staining (2o), whereas in SCI control mice the staining was significantly reduced (2p). SCH58261 attenuated the loss of positive staining for Bcl-2 in the SC from SCI-subjected mice (2q).

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Journal of Neuroinflammation

ISSN: 1742-2094