Figure 9From: Selective adenosine A2Areceptor agonists and antagonists protect against spinal cord injury through peripheral and central effects Effect of SCH58261 and CGS21680 treatment on histological alterations when centrally applied after SCI. Significant damage to the SC from SCI-operated mice in the perilesional area was assessed by the presence of edema as well as alteration of the white matter 24 h after injury (B). Notably, significant protection from SCI was observed in tissue collected from SCH58261-treated mice (D), whereas CGS21680, when locally applied on spinal cord tissue, did not protect against SCI (C). This figure is representative of at least 3 experiments performed on different experimental days. The histological score (d) was evaluated by an independent observer. ND: not detectable. *P < 0.01 vs sham; °P < 0.01 vs SCI.Back to article page