mRNA expression levels of pro-inflammatory genes in host, peritumor and tumor fractions obtained by neuronavigation. Host (H), peritumor (P) and tumor (T) tissues of GBM were obtained by neuronavigation. Each fraction was processed and mRNA obtained as described in Methods. mRNA expression levels for RAGE, P2X7R, COX2, NOS2 and PTX3 were determined by real time PCR. The bar graphs show fold increases in expression of the studied molecules in peritumor and tumor tissue with respect to host tissue, set at 0. Data are presented as mean ± SD for all GBMs analyzed (n = 10). *, P < 0.05.