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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Enhanced neuroinflammation and pain hypersensitivity after peripheral nerve injury in rats expressing mutated superoxide dismutase 1

Figure 2

Rats expressing hSOD1 G93A show enhanced pain hypersensitivity after PSNL. Rats were tested for thermal and mechanical hypersensitivity for 21 days after surgery. Paw withdrawal latencies (PWL) of the ipsilateral (A) or contralateral (B) hind paws after thermal stimulation, expressed as a percentage of the baseline PWL. PSNL induced a decrease of PWL in both WT and hSOD1G93A rats on the ipsilateral side, compared to their respective sham controls (statistics not shown). The ANOVA repeated measures revealed enhanced pain hypersensitivity for hSOD1G93A rats compared to WT rats after PSNL. (C,D) 50% paw withdrawal threshold (PWT) of the ipsilateral (C) or contralateral (D) hind paws after mechanical stimulation, expressed in grams. PSNL triggered mechanical hypersensitivity in both WT and transgenic rats (statistics not shown), but no statistical difference was evidenced between WT and transgenic rats after ligation. (E-H) Area under the curve (AUC) analysis of the corresponding graph confirmed the enhanced ipsilateral thermal hypersensitivity in transgenic rats compared to WT rats after PSNL (#p < 0.05), while mechanical hypersensitivity only tends to be amplified in transgenic rats after lesion (p = 0.08); ANOVA and Tukey post-hoc test. Each group included 6 to 8 animals.

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