Decreased levels of C/EBPδ in brain areas with high Aβ plaque burden from aged tg-ArcSwe mice. Relative abundance and representative western blot of C/EBPδ from forebrain (A) of aged tg-ArcSwe mice (tg) and non-transgenic mice (c) showing a decrease in protein levels in amyloid-rich areas whereas the relatively Aβ plaque-free hindbrain (B) does not show altered expression. The data represent mean ± SEM for six transgenic and six control mice. Young transgenic mice did not show alterations in C/EBPδ expression compared to non-transgenic littermates in forebrain (C) or hindbrain (D). The data represent mean ± SEM for three transgenic mice and five control mice. 40 μg of protein lysate was loaded in each lane and β-actin was used as a loading control. *p < 0.05, significantly different from control. A.U., arbitrary units.