Skip to main content
Figure 3 | Journal of Neuroinflammation

Figure 3

From: MyD88 is pivotal for immune recognition of Citrobacter koseri and astrocyte activation during CNS infection

Figure 3

Neutrophil and macrophage influx into C. koseri- infected brain is dictated by MyD88-dependent signaling. MyD88 KO and WT mice (5-8 per group) received intracerebral injections of C. koseri and were sacrificed at 24 h following bacterial exposure, whereupon the percentages of viable neutrophils (Ly-6G+, F4/80-, and CD45high), macrophages (Ly-6G-, F4/80+, and CD45high), and microglia (Ly-6G-, F4/80+, and CD45low-intermediate) were quantitated by FACS analysis with the vital stain 7-AAD. Results are expressed as the percentage of cells normalized to WT values (set to 100%) and represent the mean ± SEM from three independent experiments. Significant differences between MyD88 KO versus WT mice are denoted by asterisks (*, p < 0.05, **, p < 0.01, t-test).

Back to article page