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Table 3 Clinical features of patients with confirmed neuroborreliosis, stratified into two groups depending on the IL-17 level in cerebrospinal fluid.

From: Indications of Th1 and Th17 responses in cerebrospinal fluid from patients with Lyme neuroborreliosis: a large retrospective study

 

IL-17 in CSF

<0.80 pg/mL

n = 68

IL-17 in CSF

>0.80 pg/mL

n = 65

Pleocytosis

median number of cells/μL, (range)

138

(8-384)

184*

(10-1650)

CSF-albumin

S-albumin median, (range)

14.3

(3.4-59.6)

18.1

(3.8-76.0)

Median age

years, (range)

48

(3-87)

14

(3-77)

Median duration of

symptoms before LP

weeks, (range)

2.0

(0.1-25.0)

3.0

(0-32.0)

Cranial nerve palsy

n, (%)

37

(54.4)

33

(50.8)

Muscle and joint pain

n, (%)

32

(47.1)

27

(41.5)

Radiculitis

n, (%)

30

(44.1)

23

(35.4)

Neck pain

n, (%)

22

(32.4)

25

(38.5)

Headache

n, (%)

26

(28.2)

29

(44.6)

Fatigue

n, (%)

17

(25.0)

31*

(47.7)

Parestesias

n, (%)

12

(17.6)

11

(16.9)

Fever >38°C

n, (%)

10

(14.7)

16

(24.6)

Vertigo

n, (%)

4

(5.9)

6

(9.2)

Concentration difficulties

n, (%)

2

(2.9)

2

(3.1)

  1. CSF: cerebrospinal fluid.
  2. LP: lumbar puncture.
  3. S: serum.
  4. n: number of patients.
  5. °C: degrees Celsius.
  6. * significant differences between the two groups. * p < 0.01, ** p < 0.001, *** p < 0.0001.
  7. Patients could have one or several symptoms.