Figure 2From: Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease Microglial reactivity associated with plaques is not altered by the absence of C1q in the 3xTg mice on either background, although 3xTgBUB mice show a statistically significant higher CD45 reactivity than 3xTg at 12.5 m. A. CD45 immunostaining in the subiculum area of 16 m 3xTg or 3xTgQ-/- animals (Scale bar: 50 um). B. Image analysis of CD45 in representative trials at 12 and 16 m. Data points are individual animals. Bars are the average of n animals +/- SE. 12 m 3xTg n = 5, 3xTgQ-/- n = 6, 16 m 3xTg n = 4, 3xTgQ-/- n = 6. Data is representative from one of two different trials (total of at least 11 mice per genotype). C. Progression of the CD45 pathology in 3xTg, 3xTgBUB and 3xTgQ-/-BUB at different ages. Data points are the average of n animals +/- SE at ages noted. 3xTg, 3xTgBUB, 3xTgQ-/-BUB at 7 m n = 3,3,5; at 10 m n = 8,3,8; at 12.5 m n = 7,7,8; *p < 0.02 (3xTg vs 3xTgBUB) using ANOVA single factor.Back to article page