Skip to main content
Figure 2 | Journal of Neuroinflammation

Figure 2

From: Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease

Figure 2

Microglial reactivity associated with plaques is not altered by the absence of C1q in the 3xTg mice on either background, although 3xTgBUB mice show a statistically significant higher CD45 reactivity than 3xTg at 12.5 m. A. CD45 immunostaining in the subiculum area of 16 m 3xTg or 3xTgQ-/- animals (Scale bar: 50 um). B. Image analysis of CD45 in representative trials at 12 and 16 m. Data points are individual animals. Bars are the average of n animals +/- SE. 12 m 3xTg n = 5, 3xTgQ-/- n = 6, 16 m 3xTg n = 4, 3xTgQ-/- n = 6. Data is representative from one of two different trials (total of at least 11 mice per genotype). C. Progression of the CD45 pathology in 3xTg, 3xTgBUB and 3xTgQ-/-BUB at different ages. Data points are the average of n animals +/- SE at ages noted. 3xTg, 3xTgBUB, 3xTgQ-/-BUB at 7 m n = 3,3,5; at 10 m n = 8,3,8; at 12.5 m n = 7,7,8; *p < 0.02 (3xTg vs 3xTgBUB) using ANOVA single factor.

Back to article page