Skip to main content
Figure 6 | Journal of Neuroinflammation

Figure 6

From: Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease

Figure 6

C3 is expressed in astrocytes clustered around plaques in the 3xTg similarly to other APP models of AD, but is not associated with plaques as shown in the Arc48 model. C3 immunostaining using anti human C3/C3c (A) and anti human C3/C3d (B) (red) in astrocytes clustered around plaques in the subiculum of the 3xTg mice at 18 and 22 m respectively. C. Colocalization (merged image) of anti mouse C3 (clone11H9) (red) with GFAP (green) in Tg2576 15 m. D. Colocalization of anti human C3/C3d (red) with thioflavine (green) in the Arc48 model at 9 m. Merged images shows that this anti C3/C3d antibody labels astrocytes (red) and also colocalizes with thioflavine plaques (yellow). Scale bar: 50 um.

Back to article page