Fold changes of adaptor and interacting proteins of TLR pathways after TBI and treatment with PROG. The figure shows the fold changes of adaptor and interacting proteins after TBI compared with the sham group. CD14 (A), MD-1 (B), Pglyrp-1 (C) and Ticam2 (D) were significantly up-regulated). PROG did not significantly inhibit the increased adaptor and interacting proteins, but significantly up-regulated the expression of MyD88 (E) and Ticam1 (F) in mice with and without TBI compared with sham and TBI groups. Note: a: compared with sham; b: compared with sham + p; d: compared with TBI; ≥2-fold and P < 0.05; Sham: n = 3; Sham+P: n = 3; TBI: n = 5; TBI+P: n = 3.