Figure 3
Fold changes of down-stream target genes in TLR pathways after TBI and treatment with PROG. The figures show the up-regulated target genes of TLR pathways (Ccl-2, IL-1b, IL-1a, IL1r1, IL-6, TNF, Tnfrs1a, Clec4e, Cebpb, Jun, IRF-1 and Cxcl-10) after TBI compared with shams. Administration of PROG significantly reduced the expression of 3 of the increased genes in brain tissue after TBI (Ccl-2 (A), IL-1β (B) and Cxcl-10 (L) compared to TBI. Note: a: compared with sham; b: compared with sham + p; d: compared with TBI: ≥2-fold, p < 0.05; Sham: n = 3; Sham+P: n = 3; TBI: n = 5; TBI+P: n = 3.