The mRNA levels of TLR2, TLR9, Ccl-2 and Cxcl-10 in traumatically injured brain with or without progesterone treatment. The figures show that TLR2 (A), Ccl-2 (C) and Cxcl-10 (D) significantly increased in traumatically injured brain compared with sham controls. Administration of PROG down-regulated the increased mRNA levels of Ccl-2 and Cxcl-10, but did not down-regulate the mRNA levels of TLR2 and TLR9 (B) in sham and injured brain. Note: a: compared with sham; d: compared with TBI: p < 0.05. Sham: n = 3; Sham+P: n = 3; TBI: n = 3; TBI+P: n = 3.