Figure 5

Expression of TLR2, TLR9, Ccl-2 and Cxcl-10 in traumatically injured brain with or without progesterone treatment. The figures show that TLR2, Ccl-2 and Cxcl-10, but not TLR9, significantly increased in traumatically injured brain compared with sham controls. Administration of PROG inhibited the increase of Ccl-2 and Cxcl-10, but increased the expression of TLR9 in sham and injured brain. Representative images of western blots are shown on the top of A and B. Note: a: compared with sham; b: compared with TBI; d: compared with TBI: p < 0.05. Sham: n = 3; Sham+P: n = 3; TBI: n = 5; TBI+P: n = 5.