Table 1 The detected genes of interest (GOI)

Toll-like receptors

TLR1

NM_030682

2.99*

1.18

-1.33

TLR2

NM_011905

4.28*

2.82*

1.24

TLR3

NM_126166

1.20

1.82

1.20

TLR4

NM_021297

1.89*

1.54

1.05

TLR5

NM_016928

-1.28

1.49

1.47

TLR6

NM_011604

-1.12

1.88

1.70

TLR7

NM_133211

1.52

2.04

1.78

TLR8

NM_133212

1.79

3.44

1.55

TLR9

NM_031178

1.21

6.01*

3.31*

Muc13

NM_010739

1.15

-1.76

-1.39

Adaptors & interacting proteins

Btk

NM_013482

1.56

1.81

1.24

Cd14

NM_009841

7.51*

1.00

-1.84

Hmgb1

NM_010439

-1.07

1.19

1.12

Hras1

NM_008284

-1.78

1.88

2.74*

Hspa1a

NM_010479

1.97*

1.3

-1.37

Hspd1

NM_010477

1.05

-1.11

-1.21

MD-1

NM_010745

2.51*

1.06

1.02

Ly96

NM_016923

1.08

1.01

-1.07

Mapk8ip3

NM_013931

-1.09

-1.04

-1.06

MyD88

NM_010851

1.33

2.86*

2.65*

Peli1

NM_023324

-1.16

1.77

1.82

Pglyrp1

NM_009402

2.35*

1.64

1.34

Ripk2

NM_138952

1.10

1.18

1.04

Ticam1

NM_174989

-1.99

8.98*

16.18*

Ticam2

NM_173394

2.04*

4.87*

3.76*

Tirap

NM_054096

1.24

2.93

2.04*

Tollip

NM_023764

-1.09

1.12

1.11

Effectors

Casp8

NM_009812

-1.03

2.10*

2.04*

Fadd

NM_010175

1.34

6.02*

4.63*

Irak1

NM_008363

-1.09

2.11

1.82

Irak2

NM_172161

-1.16

2.05*

2.58*

Map3k7

NM_172688

-1.31

-1.01

1.08

Nr2c2

NM_011630

-1.34

1.88

2.03*

Ppara

NM_011144

-1.80

2.40*

2.72*

Eif2ak2

NM_011163

1.80

1.16

-1.37

Ube2n

NM_080560

-1.15

1.02

-1.01

Ube2v1

NM_023230

-1.11

1.44

1.45

Downstream and target genes

NFκB pathway

Ccl2

NM_011333

41.89*

1.15

-2.73*

Chuk

NM_007700

1.01

2.21

1.80

Csf2

NM_009969

1.50

1.67

-1.28

Csf3

NM_009971

3.07*

3.26*

2.32*

Hrb1 (agfg1)

NM_010472

-1.18

1.58

1.52

IKKb

NM_010546

-1.50

2.66*

3.10*

Il1a

NM_010554

2.03*

-1.23

-1.29

Il1b

NM_008361

8.69*

-1.17

-3.43*

Il1r1

NM_008362

2.16*

1.18

-1.28

Il2

NM_008366

-1.10

1.26

-1.45

Il6

NM_031168

5.17*

-2.17*

-2.33

Il10

NM_010548

2.06*

1.91

1.47

Il12a

NM_008351

1.20

1.64

1.44

Map3k1

NM_011945

-1.28

2.70

1.78

Nfkb1

NM_008689

1.03

1.26

1.09

Nfkb2

NM_019408

1.14

3.86*

3.69*

Nfkbia

NM_010907

1.22

1.29

1.35

Nfkbib

NM_010908

1.15

-1.22

-1.18

Nfkbil1

NM_010909

-1.22

5.17*

4.83*

Nfrkb

NM_172766

-1.20

1.65

1.47

Rel

NM_009044

1.11

1.12

1.03

Rela

NM_009045

-1.02

2.61*

2.6*

Tnf

NM_013693

19.31*

-1.05

-1.31

Tnfaip3

NM_009397

1.04

2.07*

2.38*

Tnfrsf1a

NM_011609

2.91*

5.1*

3.31*

Tradd

NM_001033161

1.09

-1.02

-1.14

JNK/p38 pathway

Elk1

NM_007922

-1.25

2.43*

2.13*

Fos

NM_010234

1.67

1.99

1.34

Jun

NM_010591

1.9*

1.56

1.1

Map2k3

NM_008928

1.40

1.28

-1.07

Map2k4

NM_009157

-1.26

-1.37

-1.34

Map3k1

NM_011945

-1.28

2.74

1.78

Mapk8

NM_016700

-1.45

1.73

1.94

Mapk9

NM_016961

-1.31

1.15

1.28

NF/IL6 pathway

Cebpb

NM_009883

2.06*

-1.19

-1.69

Clec4e

NM_019948

6.72*

-1.35

-1.43

Il6ra

NM_010559

1.13

1.38

1.14

Ptgs2

NM_011198

2.33*

1.99*

1.5

IRF pathway

Cxcl10

NM_021274

22.99*

-1.03

-4.46*

Ifnb1

NM_010510

1.03

-1.86

-1.66

Ifng

NM_008337

1.30

1.01

1.19

Irf1

NM_008390

1.62

1.80

1.18

Irf3

NM_016849

0.99

3.12

1.90

Tbk1

NM_019786

-1.17

1.28

1.31

Adaptive Immunity

CD80

NM_009855

1.26

1.15

1.27

CD86

NM_019388

1.20

-1.11

1.00

Traf6

NM_009424

1.24

4.57*

3.19*