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Table 1 The detected genes of interest (GOI)

From: Genomic profile of Toll-like receptor pathways in traumatically brain-injured mice: effect of exogenous progesterone

   Fold Changes
Genes RefSeq TBI/Sham Sham+P/Sham TBI+P/TBI
Toll-like receptors     
TLR1 NM_030682 2.99* 1.18 -1.33
TLR2 NM_011905 4.28* 2.82* 1.24
TLR3 NM_126166 1.20 1.82 1.20
TLR4 NM_021297 1.89* 1.54 1.05
TLR5 NM_016928 -1.28 1.49 1.47
TLR6 NM_011604 -1.12 1.88 1.70
TLR7 NM_133211 1.52 2.04 1.78
TLR8 NM_133212 1.79 3.44 1.55
TLR9 NM_031178 1.21 6.01* 3.31*
Muc13 NM_010739 1.15 -1.76 -1.39
Adaptors & interacting proteins     
Btk NM_013482 1.56 1.81 1.24
Cd14 NM_009841 7.51* 1.00 -1.84
Hmgb1 NM_010439 -1.07 1.19 1.12
Hras1 NM_008284 -1.78 1.88 2.74*
Hspa1a NM_010479 1.97* 1.3 -1.37
Hspd1 NM_010477 1.05 -1.11 -1.21
MD-1 NM_010745 2.51* 1.06 1.02
Ly96 NM_016923 1.08 1.01 -1.07
Mapk8ip3 NM_013931 -1.09 -1.04 -1.06
MyD88 NM_010851 1.33 2.86* 2.65*
Peli1 NM_023324 -1.16 1.77 1.82
Pglyrp1 NM_009402 2.35* 1.64 1.34
Ripk2 NM_138952 1.10 1.18 1.04
Ticam1 NM_174989 -1.99 8.98* 16.18*
Ticam2 NM_173394 2.04* 4.87* 3.76*
Tirap NM_054096 1.24 2.93 2.04*
Tollip NM_023764 -1.09 1.12 1.11
Effectors     
Casp8 NM_009812 -1.03 2.10* 2.04*
Fadd NM_010175 1.34 6.02* 4.63*
Irak1 NM_008363 -1.09 2.11 1.82
Irak2 NM_172161 -1.16 2.05* 2.58*
Map3k7 NM_172688 -1.31 -1.01 1.08
Nr2c2 NM_011630 -1.34 1.88 2.03*
Ppara NM_011144 -1.80 2.40* 2.72*
Eif2ak2 NM_011163 1.80 1.16 -1.37
Ube2n NM_080560 -1.15 1.02 -1.01
Ube2v1 NM_023230 -1.11 1.44 1.45
Downstream and target genes     
NFκB pathway     
Ccl2 NM_011333 41.89* 1.15 -2.73*
Chuk NM_007700 1.01 2.21 1.80
Csf2 NM_009969 1.50 1.67 -1.28
Csf3 NM_009971 3.07* 3.26* 2.32*
Hrb1 (agfg1) NM_010472 -1.18 1.58 1.52
IKKb NM_010546 -1.50 2.66* 3.10*
Il1a NM_010554 2.03* -1.23 -1.29
Il1b NM_008361 8.69* -1.17 -3.43*
Il1r1 NM_008362 2.16* 1.18 -1.28
Il2 NM_008366 -1.10 1.26 -1.45
Il6 NM_031168 5.17* -2.17* -2.33
Il10 NM_010548 2.06* 1.91 1.47
Il12a NM_008351 1.20 1.64 1.44
Map3k1 NM_011945 -1.28 2.70 1.78
Nfkb1 NM_008689 1.03 1.26 1.09
Nfkb2 NM_019408 1.14 3.86* 3.69*
Nfkbia NM_010907 1.22 1.29 1.35
Nfkbib NM_010908 1.15 -1.22 -1.18
Nfkbil1 NM_010909 -1.22 5.17* 4.83*
Nfrkb NM_172766 -1.20 1.65 1.47
Rel NM_009044 1.11 1.12 1.03
Rela NM_009045 -1.02 2.61* 2.6*
Tnf NM_013693 19.31* -1.05 -1.31
Tnfaip3 NM_009397 1.04 2.07* 2.38*
Tnfrsf1a NM_011609 2.91* 5.1* 3.31*
Tradd NM_001033161 1.09 -1.02 -1.14
JNK/p38 pathway     
Elk1 NM_007922 -1.25 2.43* 2.13*
Fos NM_010234 1.67 1.99 1.34
Jun NM_010591 1.9* 1.56 1.1
Map2k3 NM_008928 1.40 1.28 -1.07
Map2k4 NM_009157 -1.26 -1.37 -1.34
Map3k1 NM_011945 -1.28 2.74 1.78
Mapk8 NM_016700 -1.45 1.73 1.94
Mapk9 NM_016961 -1.31 1.15 1.28
NF/IL6 pathway     
Cebpb NM_009883 2.06* -1.19 -1.69
Clec4e NM_019948 6.72* -1.35 -1.43
Il6ra NM_010559 1.13 1.38 1.14
Ptgs2 NM_011198 2.33* 1.99* 1.5
IRF pathway     
Cxcl10 NM_021274 22.99* -1.03 -4.46*
Ifnb1 NM_010510 1.03 -1.86 -1.66
Ifng NM_008337 1.30 1.01 1.19
Irf1 NM_008390 1.62 1.80 1.18
Irf3 NM_016849 0.99 3.12 1.90
Tbk1 NM_019786 -1.17 1.28 1.31
Adaptive Immunity     
CD80 NM_009855 1.26 1.15 1.27
CD86 NM_019388 1.20 -1.11 1.00
Traf6 NM_009424 1.24 4.57* 3.19*
  1. Note: Positive fold change indicates up-regulation. Negative fold change indicates down-regulation. *p < 0.05
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