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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Regulation of Toll-like receptor 1 and -2 in neonatal mice brains after hypoxia-ischemia

Figure 4

TLR-2 is expressed in astrocytes and neurons. A: Triple immunofluorescence staining for TLR-2, Iba-1 and HuC/D; the merged image indicates mutually exclusive expression of TLR-2, Iba-1 and HuC/D positive cells in the ipsilateral hippocampus. B: Triple immunofluorescence staining for TLR-2, GFAP and Olig2; the merged picture displays apparent co-expression of TLR-2 and GFAP. C: High magnification XYZ, XZ, YZ-average projections of TLR-2 and GFAP co-expressing cells; TLR-2 appears to be associated with cytoskeletal protein GFAP in astrocytes. Pictures A-C were captured in the ipsilateral hippocampus. D: High magnification orthogonal views of TLR-2 and HuC/D double stains in cells in the paraventricular nucleus of the hypothalamus (PVN); the merged picture shows punctate, membranous expression of TLR-2 on HuC/D positive neurons of the PVN. Scale bars: A-B: 25 μm C-D: 10 μm

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