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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis

Figure 3

Transcripts for pro-inflammatory cytokine/chemokines are increased in the lumbar spinal cord of Axl-/- mice relative to WT during the acute phase of EAE. a) 45.7-fold increase of TNF⍺ transcript in Axl-/- and WT lumbar spinal cord (combined) during the acute phase of EAE relative to naïve Axl-/- and WT mice (combined); 68.8-fold increase in Axl-/- EAE mice relative to untreated Axl-/-; 18.7-fold increase in WT EAE mice relative to WT untreated mice. b) Increased TNF⍺, MCP1 and RANTES transcripts were found in Axl-/- lumbar spinal cord compared to WT. Samples of RNA from lumbar spinal cord were grouped as untreated (non-MOG EAE-induced), mice with CI's ≤ 2, or mice with CI's > 2. The fold increase of pro-inflammatory cytokine/chemokines in Axl-/- lumbar spinal cord relative to WT lumbar spinal cord was determined. Fold increase for CI ≤ 2; TNF⍺ = 8.1, MCP1 = 7.2, RANTES = 11.9. * p < 0.05, # p < 0.001.

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Journal of Neuroinflammation

ISSN: 1742-2094