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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis

Figure 6

Axl-/- mice have significantly fewer Iba1+ microglia/macrophages within and surrounding lesions than WT mice. Ten micron frozen WT and Axl-/- spinal cord sections were stained with an Iba1 pAb. Representative 40× images for WT (a) and Axl-/- (b) mice are shown. The arrows point to Iba1+ microglia/macrophages and the asterisks denote lesion area. c) Iba1+ activated microglia were counted in and surrounding multiple lesions in multiple mice for WT and Axl-/- mice. Statistical analysis was performed; student's t-test confirmed significance between WT and Axl-/- mice; p < 0.01.

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Journal of Neuroinflammation

ISSN: 1742-2094