Figure 1From: Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1β and IL-6 Impact of dexamethasone-21-phosphate on LPS-induced core body temperature and activity changes. a) The deviation of core body temperature, at 3.5 hours, from baseline (t = 0) in normal brain homogenate (NBH) or ME7 animals treated with saline or LPS (500 μg/kg), pre-treated with dexamethasone-21-phosphate (DEX; 2 mg/kg) or sterile saline. ** p < 0.01, *** p < 0.001 by Bonferroni post-hoc test after a significant main effect of treatment by one-way ANOVA. n = 9 (NBH+saline), n = 6 (NBH+LPS), n = 10 (ME7+saline, ME7+LPS), n = 8 (ME7+LPS+dex) and n = 5 for all other groups. b) Rearing activity at 2 hours post-challenge with LPS expressed as a percentage of baseline rears (-24 hours). *p < 0.05, ** p < 0.01 by Bonferroni post-hoc test after a significant main effect of treatment by one-way ANOVA. In assessment of rears n = 4 for all groups except ME7+LPS+dex (n = 5), NBH+saline (n = 10). All data have been presented as mean ± SEM.Back to article page