Figure 3
Impact of dexamethasone-21-phosphate on LPS-induced CNS cytokine transcription. TAQMAN quantitative PCR mRNA expression analysis of a) IL-1β, b) TNFα, c) IL-6 and d) TGFβ1. LPS (500 μg/kg) induced marked expression of all cytokines except TGFβ1 but dexamethasone-21-phosphate did not inhibit this transcription in most cases (p >> 0.05). Data were analysed by Bonferroni post-hoc test after a significant main effect of treatment by one-way ANOVA, ** p < 0.01, *** p < 0.001. n = 9 for ME7+saline, n = 4 for NBH+dex and NBH+LPS and n = 5 for all other groups. All data have been presented as mean ± SEM.