Figure 6
Effect of intracerebroventricular injection of sIL-1RI on the MDMA-induced reduction of 5-HT transporters in frontal cortex and hypothalamus (a,b), cortical 5-HT concentration (c) and hyperthermia (d). sIL-1RI (3 μg) was administered 5 min before and 3 h after MDMA (12.5 mg/kg, i.p.), rats being killed 7 days later. Results shown as mean ± SEM (n = 5-9). Different from vehicle + saline group: *p < 0.05, ** p < 0.01, ***p < 0.001. Different from vehicle + MDMA-treated group: f p < 0.05. In panel (d) different from vehicle + saline group: *p < 0.001.