TY - JOUR AU - Maier, S. F. AU - Goehler, L. E. AU - Fleshner, M. AU - Watkins, L. R. PY - 1998 DA - 1998// TI - The role of the vagus nerve in cytokine-to-brain communication JO - Neuroimmunomodulation VL - 840 ID - Maier1998 ER - TY - JOUR AU - Quan, N. PY - 2008 DA - 2008// TI - Immune-to-brain signaling: How important are the blood-brain barrier-independent pathways? JO - Molecular Neurobiology VL - 37 UR - https://doi.org/10.1007/s12035-008-8026-z DO - 10.1007/s12035-008-8026-z ID - Quan2008 ER - TY - JOUR AU - Ransohoff, R. M. AU - Perry, V. H. PY - 2009 DA - 2009// TI - Microglial Physiology: Unique Stimuli, Specialized Responses JO - Annual Review of Immunology VL - 27 UR - https://doi.org/10.1146/annurev.immunol.021908.132528 DO - 10.1146/annurev.immunol.021908.132528 ID - Ransohoff2009 ER - TY - JOUR AU - Kelley, K. W. AU - Bluthe, R. M. AU - Dantzer, R. AU - Zhou, J. H. AU - Shen, W. H. AU - Johnson, R. W. AU - Broussard, S. R. PY - 2003 DA - 2003// TI - Cytokine-induced sickness behavior JO - Brain Behavior and Immunity VL - 17 UR - https://doi.org/10.1016/S0889-1591(02)00077-6 DO - 10.1016/S0889-1591(02)00077-6 ID - Kelley2003 ER - TY - JOUR AU - Abraham, J. AU - Johnson, R. W. PY - 2009 DA - 2009// TI - Central inhibition of interleukin-1 beta ameliorates sickness behavior in aged mice JO - Brain Behavior and Immunity VL - 23 UR - https://doi.org/10.1016/j.bbi.2008.12.008 DO - 10.1016/j.bbi.2008.12.008 ID - Abraham2009 ER - TY - JOUR AU - Combrinck, M. I. AU - Perry, V. H. AU - Cunningham, C. PY - 2002 DA - 2002// TI - Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease JO - Neuroscience VL - 112 UR - https://doi.org/10.1016/S0306-4522(02)00030-1 DO - 10.1016/S0306-4522(02)00030-1 ID - Combrinck2002 ER - TY - JOUR AU - Godbout, J. P. AU - Chen, J. AU - Abraham, J. AU - Richwine, A. F. AU - Berg, B. M. AU - Kelley, K. W. AU - Johnson, R. W. PY - 2005 DA - 2005// TI - Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system JO - Faseb Journal VL - 19 ID - Godbout2005 ER - TY - JOUR AU - Huang, Y. AU - Henry, C. J. AU - Dantzer, R. AU - Johnson, R. W. AU - Godbout, J. P. PY - 2008 DA - 2008// TI - Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide JO - Neurobiology of Aging VL - 29 UR - https://doi.org/10.1016/j.neurobiolaging.2007.04.012 DO - 10.1016/j.neurobiolaging.2007.04.012 ID - Huang2008 ER - TY - JOUR AU - Campbell, I. L. AU - Abraham, C. R. AU - Masliah, E. AU - Kemper, P. AU - Inglis, J. D. AU - Oldstone, M. B. A. AU - Mucke, L. PY - 1993 DA - 1993// TI - Neurologic disease induced in transgenic mice by cerebral overexpression of Interleukin-6 JO - Proceedings of the National Academy of Sciences of the United States of America VL - 90 UR - https://doi.org/10.1073/pnas.90.21.10061 DO - 10.1073/pnas.90.21.10061 ID - Campbell1993 ER - TY - JOUR AU - Chen, J. AU - Buchanan, J. B. AU - Sparkman, N. L. AU - Godbout, J. P. AU - Freund, G. G. AU - Johnson, R. W. PY - 2008 DA - 2008// TI - Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system JO - Brain Behavior and Immunity VL - 22 UR - https://doi.org/10.1016/j.bbi.2007.08.014 DO - 10.1016/j.bbi.2007.08.014 ID - Chen2008 ER - TY - JOUR AU - Heyser, C. J. AU - Masliah, E. AU - Samimi, A. AU - Campbell, I. L. AU - Gold, L. H. PY - 1997 DA - 1997// TI - Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain JO - Proceedings of the National Academy of Sciences of the United States of America VL - 94 UR - https://doi.org/10.1073/pnas.94.4.1500 DO - 10.1073/pnas.94.4.1500 ID - Heyser1997 ER - TY - JOUR AU - Mines, M. A. AU - Yuskaitis, C. J. AU - King, M. K. AU - Beurel, E. AU - Jope, R. S. PY - 2010 DA - 2010// TI - GSK3 Influences Social Preference and Anxiety-Related Behaviors during Social Interaction in a Mouse Model of Fragile X Syndrome and Autism JO - Plos One VL - 5 UR - https://doi.org/10.1371/journal.pone.0009706 DO - 10.1371/journal.pone.0009706 ID - Mines2010 ER - TY - JOUR AU - Sparkman, N. L. AU - Johnson, R. W. PY - 2008 DA - 2008// TI - Neuroinflammation Associated with Aging Sensitizes the Brain to the Effects of Infection or Stress JO - Neuroimmunomodulation VL - 15 UR - https://doi.org/10.1159/000156474 DO - 10.1159/000156474 ID - Sparkman2008 ER - TY - JOUR AU - Sparkman, N. L. AU - Buchanan, J. B. AU - Heyen, J. R. R. AU - Chen, J. AU - Beverly, J. L. AU - Johnson, R. W. PY - 2006 DA - 2006// TI - Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers JO - Journal of Neuroscience VL - 26 UR - https://doi.org/10.1523/JNEUROSCI.3376-06.2006 DO - 10.1523/JNEUROSCI.3376-06.2006 ID - Sparkman2006 ER - TY - JOUR AU - Heinrich, P. C. AU - Behrmann, I. AU - Muller-Newen, G. AU - Schaper, F. AU - Graeve, L. PY - 1998 DA - 1998// TI - Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway JO - Biochemical Journal VL - 334 UR - https://doi.org/10.1042/bj3340297 DO - 10.1042/bj3340297 ID - Heinrich1998 ER - TY - JOUR AU - Kishimoto, T. AU - Akira, S. AU - Taga, T. PY - 1992 DA - 1992// TI - IL-6 receptor and mechanism of signal transduction JO - International Journal of Immunopharmacology VL - 14 UR - https://doi.org/10.1016/0192-0561(92)90173-I DO - 10.1016/0192-0561(92)90173-I ID - Kishimoto1992 ER - TY - JOUR AU - Rosejohn, S. AU - Heinrich, P. C. PY - 1994 DA - 1994// TI - Soluble receptors for cytokines and growth factors - generation and biological function JO - Biochemical Journal VL - 300 UR - https://doi.org/10.1042/bj3000281 DO - 10.1042/bj3000281 ID - Rosejohn1994 ER - TY - JOUR AU - Jones, S. A. AU - Richards, P. J. AU - Scheller, J. AU - Rose-John, S. PY - 2005 DA - 2005// TI - IL-6 transsignaling: The in vivo consequences JO - Journal of Interferon and Cytokine Research VL - 25 UR - https://doi.org/10.1089/jir.2005.25.241 DO - 10.1089/jir.2005.25.241 ID - Jones2005 ER - TY - JOUR AU - Jostock, T. AU - Mullberg, J. AU - Ozbek, S. AU - Atreya, R. AU - Blinn, G. AU - Voltz, N. AU - Fischer, M. AU - Neurath, M. F. AU - Rose-John, S. PY - 2001 DA - 2001// TI - Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses JO - European Journal of Biochemistry VL - 268 UR - https://doi.org/10.1046/j.1432-1327.2001.01867.x DO - 10.1046/j.1432-1327.2001.01867.x ID - Jostock2001 ER - TY - JOUR AU - Diehl, S. AU - Rincon, M. PY - 2002 DA - 2002// TI - The two faces of IL-6 on Th1/Th2 differentiation JO - Molecular Immunology VL - 39 UR - https://doi.org/10.1016/S0161-5890(02)00210-9 DO - 10.1016/S0161-5890(02)00210-9 ID - Diehl2002 ER - TY - JOUR AU - Mudter, J. AU - Neurath, M. F. PY - 2007 DA - 2007// TI - IL-6 signaling in inflammatory bowel disease: Pathophysiological role and clinical relevance JO - Inflammatory Bowel Diseases VL - 13 UR - https://doi.org/10.1002/ibd.20148 DO - 10.1002/ibd.20148 ID - Mudter2007 ER - TY - JOUR AU - Jang, S. AU - Kelley, K. W. AU - Johnson, R. W. PY - 2008 DA - 2008// TI - Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1 JO - Proceedings of the National Academy of Sciences of the United States of America VL - 105 UR - https://doi.org/10.1073/pnas.0802865105 DO - 10.1073/pnas.0802865105 ID - Jang2008 ER - TY - JOUR AU - Zorina, Y. AU - Iyengar, R. AU - Bromberg, K. D. PY - 2010 DA - 2010// TI - Cannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowth JO - Journal of Biological Chemistry VL - 285 UR - https://doi.org/10.1074/jbc.M109.049841 DO - 10.1074/jbc.M109.049841 ID - Zorina2010 ER - TY - CHAP AU - Henry, C. J. AU - Huang, Y. AU - Wynne, A. AU - Hanke, M. AU - Himler, J. AU - Bailey, M. T. AU - Sheridan, J. F. AU - Godbout, J. P. PY - 2008 DA - 2008// TI - Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia BT - Journal of Neuroinflammation ID - Henry2008 ER - TY - JOUR AU - Abraham, J. AU - Jang, S. AU - Godbout, J. P. AU - Chen, J. AU - Kelley, K. W. AU - Dantzer, R. AU - Johnson, R. W. PY - 2008 DA - 2008// TI - Aging sensitizes mice to behavioral deficits induced by central HIV-1 gp120 JO - Neurobiology of Aging VL - 29 UR - https://doi.org/10.1016/j.neurobiolaging.2006.11.002 DO - 10.1016/j.neurobiolaging.2006.11.002 ID - Abraham2008 ER - TY - JOUR AU - Berg, B. M. AU - Godbout, J. P. AU - Kelley, K. W. AU - Johnson, R. W. PY - 2004 DA - 2004// TI - alpha-Tocopherol attenuates lipopolysaccharide-induced sickness behavior in mice JO - Brain Behavior and Immunity VL - 18 UR - https://doi.org/10.1016/S0889-1591(03)00113-2 DO - 10.1016/S0889-1591(03)00113-2 ID - Berg2004 ER - TY - JOUR AU - Krzyszton, C. P. AU - Sparkman, N. L. AU - Grant, R. W. AU - Buchanan, J. B. AU - Broussard, S. R. AU - Woods, J. AU - Johnson, R. W. PY - 2008 DA - 2008// TI - Exacerbated fatigue and motor deficits in interleukin-10-deficient mice after peripheral immune stimulation JO - American Journal of Physiology-Regulatory Integrative and Comparative Physiology VL - 295 UR - https://doi.org/10.1152/ajpregu.90302.2008 DO - 10.1152/ajpregu.90302.2008 ID - Krzyszton2008 ER - TY - JOUR AU - Marz, P. AU - Otten, U. AU - Rose-John, S. PY - 1999 DA - 1999// TI - Neural activities of IL-6-type cytokines often depend on soluble cytokine receptors JO - European Journal of Neuroscience VL - 11 UR - https://doi.org/10.1046/j.1460-9568.1999.00755.x DO - 10.1046/j.1460-9568.1999.00755.x ID - Marz1999 ER - TY - JOUR AU - Schobitz, B. AU - Pezeshki, G. AU - Pohl, T. AU - Hemmann, U. AU - Heinrich, P. C. AU - Holsboer, F. AU - Reul, J. PY - 1995 DA - 1995// TI - Soluble Interleukin-6 (IL-6) receptor augments central effects of IL-6 in vivo JO - Faseb Journal VL - 9 ID - Schobitz1995 ER - TY - JOUR AU - Dreuw, A. AU - Radtke, S. AU - Pflanz, S. AU - Lippok, B. E. AU - Heinrich, P. C. AU - Hermanns, H. M. PY - 2004 DA - 2004// TI - Characterization of the signaling capacities of the novel gp130-like cytokine receptor JO - Journal of Biological Chemistry VL - 279 UR - https://doi.org/10.1074/jbc.M401122200 DO - 10.1074/jbc.M401122200 ID - Dreuw2004 ER - TY - JOUR AU - Taga, T. AU - Kishimoto, T. PY - 1997 DA - 1997// TI - gp130 and the interleukin-6 family of cytokines JO - Annual Review of Immunology VL - 15 UR - https://doi.org/10.1146/annurev.immunol.15.1.797 DO - 10.1146/annurev.immunol.15.1.797 ID - Taga1997 ER - TY - JOUR AU - Jones, S. A. AU - Rose-John, S. PY - 2002 DA - 2002// TI - The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex JO - Biochimica Et Biophysica Acta-Molecular Cell Research VL - 1592 UR - https://doi.org/10.1016/S0167-4889(02)00319-1 DO - 10.1016/S0167-4889(02)00319-1 ID - Jones2002 ER - TY - JOUR AU - Dantzer, R. AU - Bluthe, R. M. AU - Gheusi, G. AU - Cremona, S. AU - Laye, S. AU - Parnet, P. AU - Kelley, K. W. PY - 1998 DA - 1998// TI - Molecular basis of sickness behavior JO - Molecular Mechanisms of Fever VL - 856 ID - Dantzer1998 ER - TY - JOUR AU - Mizuguchi, H. AU - Mizuno, H. AU - Yasukawa, K. AU - Ishiguro, T. AU - Fukui, K. AU - Imanaka, T. AU - Takagi, M. PY - 2001 DA - 2001// TI - Enhanced signal transduction by a directly fused protein of interleukin-6 and its receptor JO - Journal of Bioscience and Bioengineering VL - 91 UR - https://doi.org/10.1016/S1389-1723(01)80138-9 DO - 10.1016/S1389-1723(01)80138-9 ID - Mizuguchi2001 ER - TY - JOUR AU - Nancey, S. AU - Hamzaoui, N. AU - Moussata, D. AU - Graber, I. AU - Bienvenu, J. AU - Flourie, B. PY - 2008 DA - 2008// TI - Serum interleukin-6, soluble interleukin-6 receptor and Crohn's disease activity JO - Digestive Diseases and Sciences VL - 53 UR - https://doi.org/10.1007/s10620-007-9849-6 DO - 10.1007/s10620-007-9849-6 ID - Nancey2008 ER - TY - JOUR AU - Laflamme, N. AU - Rivest, S. PY - 2001 DA - 2001// TI - Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components JO - Faseb Journal VL - 15 UR - https://doi.org/10.1096/fj.00-0339com DO - 10.1096/fj.00-0339com ID - Laflamme2001 ER - TY - JOUR AU - Modrell, B. AU - Liu, J. W. AU - Miller, H. AU - Shoyab, M. PY - 1994 DA - 1994// TI - LIF and OSM directly interact with a soluble form of gp130, the IL-6 receptor signal-transducing subunit JO - Growth Factors VL - 11 UR - https://doi.org/10.3109/08977199409001050 DO - 10.3109/08977199409001050 ID - Modrell1994 ER - TY - JOUR AU - Coles, B. AU - Fielding, C. A. AU - Rose-John, S. AU - Scheller, J. AU - Jones, S. A. AU - O'Donnell, V. B. PY - 2007 DA - 2007// TI - Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo JO - American Journal of Pathology VL - 171 UR - https://doi.org/10.2353/ajpath.2007.061078 DO - 10.2353/ajpath.2007.061078 ID - Coles2007 ER - TY - JOUR AU - McLoughlin, R. M. AU - Jenkins, B. J. AU - Grail, D. AU - Williams, A. S. AU - Fielding, C. A. AU - Parker, C. R. AU - Ernst, M. AU - Topley, N. AU - Jones, S. A. PY - 2005 DA - 2005// TI - IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation JO - Proceedings of the National Academy of Sciences of the United States of America VL - 102 UR - https://doi.org/10.1073/pnas.0501794102 DO - 10.1073/pnas.0501794102 ID - McLoughlin2005 ER - TY - JOUR AU - Richards, P. J. AU - Nowell, M. A. AU - Horiuchi, S. AU - McLoughlin, R. M. AU - Fielding, C. A. AU - Grau, S. AU - Yamamoto, N. AU - Ehrmann, M. AU - Rose-John, S. AU - Williams, A. S. PY - 2006 DA - 2006// TI - Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis JO - Arthritis and Rheumatism VL - 54 UR - https://doi.org/10.1002/art.21818 DO - 10.1002/art.21818 ID - Richards2006 ER - TY - JOUR AU - Block, M. L. AU - Zecca, L. AU - Hong, J. S. PY - 2007 DA - 2007// TI - Microglia-mediated neurotoxicity: uncovering the molecular mechanisms JO - Nature Reviews Neuroscience VL - 8 UR - https://doi.org/10.1038/nrn2038 DO - 10.1038/nrn2038 ID - Block2007 ER - TY - JOUR AU - Kreutzberg, G. W. PY - 1996 DA - 1996// TI - Microglia: A sensor for pathological events in the CNS JO - Trends in Neurosciences VL - 19 UR - https://doi.org/10.1016/0166-2236(96)10049-7 DO - 10.1016/0166-2236(96)10049-7 ID - Kreutzberg1996 ER - TY - JOUR AU - Maier, S. F. AU - Watkins, L. R. PY - 1998 DA - 1998// TI - Cytokines for psychologists: Implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition JO - Psychological Review VL - 105 UR - https://doi.org/10.1037/0033-295X.105.1.83 DO - 10.1037/0033-295X.105.1.83 ID - Maier1998 ER - TY - JOUR AU - Godbout, J. P. AU - Berg, B. M. AU - Kelley, K. W. AU - Johnson, R. W. PY - 2004 DA - 2004// TI - alpha-Tocopherol reduces lipopolysaccharide-induced peroxide radical formation and interleukin-6 secretion in primary murine microglia and in brain JO - Journal of Neuroimmunology VL - 149 UR - https://doi.org/10.1016/j.jneuroim.2003.12.017 DO - 10.1016/j.jneuroim.2003.12.017 ID - Godbout2004 ER - TY - JOUR AU - Godbout, J. P. AU - Berg, G. M. AU - Krzyszton, C. AU - Johnson, R. W. PY - 2005 DA - 2005// TI - alpha-Tocopherol attenuates NF kappa B activation and pro-inflammatory cytokine production in brain and improves recovery from lipopolysaccharide-induced sickness behavior JO - Journal of Neuroimmunology VL - 169 UR - https://doi.org/10.1016/j.jneuroim.2005.08.003 DO - 10.1016/j.jneuroim.2005.08.003 ID - Godbout2005 ER - TY - JOUR AU - Swiergiel, A. H. AU - Dunn, A. J. PY - 1999 DA - 1999// TI - The roles of IL-1, IL-6, and TNF alpha in the feeding responses to endotoxin and influenza virus infection in mice JO - Brain Behavior and Immunity VL - 13 UR - https://doi.org/10.1006/brbi.1999.0565 DO - 10.1006/brbi.1999.0565 ID - Swiergiel1999 ER - TY - JOUR AU - Abraham, J. AU - Johnson, R. W. PY - 2009 DA - 2009// TI - Consuming a Diet Supplemented with Resveratrol Reduced Infection-Related Neuroinflammation and Deficits in Working Memory in Aged Mice JO - Rejuvenation Research VL - 12 UR - https://doi.org/10.1089/rej.2009.0888 DO - 10.1089/rej.2009.0888 ID - Abraham2009 ER - TY - JOUR AU - Berg, B. M. AU - Godbout, J. P. AU - Chen, J. AU - Kelley, K. W. AU - Johnson, R. W. PY - 2005 DA - 2005// TI - alpha-tocopherol and selenium facilitate recovery from lipopolysaccharide-induced sickness in aged mice JO - Journal of Nutrition VL - 135 ID - Berg2005 ER - TY - JOUR AU - Richwine, A. F. AU - Godbout, J. P. AU - Berg, B. M. AU - Chen, J. AU - Escobar, J. AU - Millard, D. K. AU - Johnson, R. W. PY - 2005 DA - 2005// TI - Improved psychomotor performance in aged mice fed diet high in antioxidants is associated with reduced ex vivo brain interleukin-6 production JO - Brain Behavior and Immunity VL - 19 UR - https://doi.org/10.1016/j.bbi.2004.12.005 DO - 10.1016/j.bbi.2004.12.005 ID - Richwine2005 ER - TY - JOUR AU - Ye, S. M. AU - Johnson, R. W. PY - 1999 DA - 1999// TI - Increased interleukin-6 expression by microglia from brain of aged mice JO - Journal of Neuroimmunology VL - 93 UR - https://doi.org/10.1016/S0165-5728(98)00217-3 DO - 10.1016/S0165-5728(98)00217-3 ID - Ye1999 ER - TY - JOUR AU - Saebyeol, J. AU - Dilger, R. N. AU - Johnson, R. W. PY - 2010 DA - 2010// TI - Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice JO - Journal of Nutrition VL - 140 UR - https://doi.org/10.3945/jn.110.123273 DO - 10.3945/jn.110.123273 ID - Saebyeol2010 ER - TY - JOUR AU - Chen, Q. AU - Wang, W. C. AU - Bruce, R. AU - Li, H. AU - Schleider, D. M. AU - Mulbury, M. J. AU - Bain, M. D. AU - Wallace, P. K. AU - Baumann, H. AU - Evans, S. S. PY - 2004 DA - 2004// TI - Central role of IL-6 receptor signal-transducing chain gp130 in activation of L-selectin adhesion by fever-range thermal stress JO - Immunity VL - 20 UR - https://doi.org/10.1016/S1074-7613(03)00358-3 DO - 10.1016/S1074-7613(03)00358-3 ID - Chen2004 ER - TY - JOUR AU - Fielding, C. A. AU - McLoughlin, R. M. AU - McLeod, L. AU - Colmont, C. S. AU - Najdovska, M. AU - Grail, D. AU - Ernst, M. AU - Jones, S. A. AU - Topley, N. AU - Jenkins, B. J. PY - 2008 DA - 2008// TI - IL-6 regulates neutrophil trafficking during acute inflammation via STAT3 JO - Journal of Immunology VL - 181 UR - https://doi.org/10.4049/jimmunol.181.3.2189 DO - 10.4049/jimmunol.181.3.2189 ID - Fielding2008 ER - TY - JOUR AU - Atreya, R. AU - Finotto, S. AU - Mudter, J. AU - Mullberg, J. AU - Jostock, T. AU - Holtmann, M. AU - Kishimoto, T. AU - Galle, P. R. AU - Rose-John, S. AU - Neurath, M. F. PY - 2000 DA - 2000// TI - Blockade of IL-6 transsignaling abrogates established experimental colitis in mice by suppression of T cell resistance against apoptosis JO - Gastroenterology VL - 118 UR - https://doi.org/10.1016/S0016-5085(00)85593-6 DO - 10.1016/S0016-5085(00)85593-6 ID - Atreya2000 ER -