Suppression of EAE clinical signs by 1,25(OH)2D3 occurs in wildtype but not STAT6 null mice. A) Wildtype (WT) EAE-induced mice were treated with DMSO vehicle as controls, or with 1,25(OH)2D3 (denoted as Vit D). There was complete suppression of clinical signs in the 1,25(OH)2D3 treated group. N = 5 mice per group, and the trend of results has been reproduced in 2 other experiments. B) EAE was not suppressed in STAT6 null (knockout, KO) mice by treatment with 1,25(OH)2D3, using the identical dose regimen as for wildtype mice in panel A (100ng ip, beginning at MOG immunization, and administered every other day). N = 5 mice per group, repeated twice with similar results.