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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain

Figure 4

Effects of intrathecal ketamine on SNL-induced mechanical allodynia. SNL induced significant mechanical allodynia as shown by von-Frey tests. Intrathecal 300 μg kg-1 ketamine did not change the normal pain threshold of the sham-operated group. Intrathecal ketamine (100 and 300 μg kg-1) showed an effective and reliable anti-allodynia effect in a dose-dependent manner on SNL-induced neuropathic pain, whereas, intrathecally 30 μg kg-1 of ketamine did not influence pain threshold after SNL at all. Drugs were given intrathecally once a day from POD 8 to POD 10. *P < 0.05, compared with that of SNL-Saline group. # P < 0.05, compared with that of SNL-ketamine 100 μg kg-1 group. There were ten rats in each group. KTM: ketamine.

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