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Figure 2 | Journal of Neuroinflammation

Figure 2

From: P2X7 receptor activation ameliorates CA3 neuronal damage via a tumor necrosis factor-α-mediated pathway in the rat hippocampus following status epilepticus

Figure 2

Effects of BzATP, OxATP, sTNFp55R, and BzATP+sTNFp55R infusion on TNF-α expression following SE. (A) TNF-α expression in dentate granule cells and the CA3 region 2 days after SE. Bar = 100 μm (panel 1). (B) TNF-α expression in mossy fibers in saline-and BzATP-infused animals 2 days after SE. In BzATP-infused animals, TNF-α immunoreactivity is colocalized with CB, a marker for mossy fibers. Bar = 100 μm (panel 1). (C) Quantitative analysis of TNF-α immunoreactivity in dentate granule cells following SE (mean ± S.E.M). *Value is significantly different from saline-infused animals, p < 0.05. (D) Quantitative analysis of TNF-α immunoreactivity in the CA3 region following SE (mean ± S.E.M). *Value is significantly different from saline-infused animals, p < 0.05.

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Journal of Neuroinflammation

ISSN: 1742-2094