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Table 1 Characteristics of subjects included in the study

From: Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients

  Healthy controls FTLD
   FTLD PGRN- FTD PGRN+
Total number 59 78 14
Gender (female), % 57 44 60
Age, years 65.2 ± 1.0 65.5 ± 0.8 63.3 ± 2.3
Diagnosis, bvFTD/PPA, % - 75.6/24.4 71.4/28.6
MMSE, score 29.1 ± 0.13 21.3 ± 0.8* 18.5 ± 3.0*
Progranulin, ng/ml n.a. 179.7 ± 6.6 63.4 ± 9.2**
  1. FTLD: frontotemporal lobar degeneration; PGRN-: no progranulin pathogenetic mutations; PGRN+: progranulin pathogenetic mutations.
  2. Results are expressed as mean ± SEM (standard error), or otherwise specified. n.a.: not available
  3. * P < 0.0001, significantly different from healthy control subjects
  4. ** P < 0.0001, significantly different from FTLD