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Table 1 Characteristics of subjects included in the study

From: Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients

 

Healthy controls

FTLD

  

FTLD PGRN-

FTD PGRN+

Total number

59

78

14

Gender (female), %

57

44

60

Age, years

65.2 ± 1.0

65.5 ± 0.8

63.3 ± 2.3

Diagnosis, bvFTD/PPA, %

-

75.6/24.4

71.4/28.6

MMSE, score

29.1 ± 0.13

21.3 ± 0.8*

18.5 ± 3.0*

Progranulin, ng/ml

n.a.

179.7 ± 6.6

63.4 ± 9.2**

  1. FTLD: frontotemporal lobar degeneration; PGRN-: no progranulin pathogenetic mutations; PGRN+: progranulin pathogenetic mutations.
  2. Results are expressed as mean ± SEM (standard error), or otherwise specified. n.a.: not available
  3. * P < 0.0001, significantly different from healthy control subjects
  4. ** P < 0.0001, significantly different from FTLD
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Journal of Neuroinflammation

ISSN: 1742-2094