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Table 2 Characteristics of asymptomatic subjects included in the study

From: Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients

 

Young healthy controls

Asymptomatic subjects

  

ASYMP-PGRN-

ASYMP-PGRN+

Total number

18

14

11

Gender (females %)

61.1

57.1

41.7

Age, years (mean ± SEM)

42.2 ± 3.1

43.7 ± 3.2

42.9 ± 4.6

MMSE, score (mean ± SEM)

29.7 ± 0.2

30 ± 0.0

29.25 ± 0.5

Progranulin, ng/ml (mean ± SEM)

n.a.

204.3 ± 25.5

58.6 ± 17.4**

  1. ** P < 0.0001, significantly different from ASYMP-PGRN-.
  2. ASYMP-PGRN-: young asymptomatic subjects with no pathogenic progranulin mutations; ASYMP-PGRN+: young asymptomatic subjects with pathogenic progranulin mutations.
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Journal of Neuroinflammation

ISSN: 1742-2094