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Table 2 Characteristics of asymptomatic subjects included in the study

From: Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients

  Young healthy controls Asymptomatic subjects
   ASYMP-PGRN- ASYMP-PGRN+
Total number 18 14 11
Gender (females %) 61.1 57.1 41.7
Age, years (mean ± SEM) 42.2 ± 3.1 43.7 ± 3.2 42.9 ± 4.6
MMSE, score (mean ± SEM) 29.7 ± 0.2 30 ± 0.0 29.25 ± 0.5
Progranulin, ng/ml (mean ± SEM) n.a. 204.3 ± 25.5 58.6 ± 17.4**
  1. ** P < 0.0001, significantly different from ASYMP-PGRN-.
  2. ASYMP-PGRN-: young asymptomatic subjects with no pathogenic progranulin mutations; ASYMP-PGRN+: young asymptomatic subjects with pathogenic progranulin mutations.