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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Reduced spiral ganglion neuronal loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis

Figure 2

Adjunctive dexamethason and NT-3 decrease hearing loss. Mice were assessed for (A) click stimuli, (B) low frequency hearing (1 kHz stimuli), and (C) high frequency hearing (10 kHz stimuli). In infected animals, a significant increase of hearing thresholds was observed. The elevation of hearing thresholds was most severe for high frequency hearing. Adjunctive treatment with dexamethasone or NT-3 improved hearing significantly compared to mice treated with ceftriaxone plus placebo. There was no difference between dexamethasone and NT-3 treated animals. (#) P < 0.05 as compared to uninfected controls, (*) p < 0.05 as compared to infected animals receiving ceftriaxone and placebo.

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