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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Reduced spiral ganglion neuronal loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis

Figure 4

Adjunctive dexamethasone and NT-3 decrease spiral ganglion neuronal loss. (A) The density of intact neurons in the spiral ganglion of the cochlea was significantly reduced in PLC-treated animals two weeks after infection compared to uninfected control animals. Treatment with dexamethasone as well as NT-3 counteracted this decline and led to a decreased loss of neurons. (B) The scala tympani of cochleae of infected mice (PLC) were occluded with dense fibrocytic tissue which was not observed in healthy uninfected control animals (CON). Adjunctive dexamethasone or NT-3 did not have an impact on cochlear occlusion. (#) P < 0.05 as compared to uninfected controls, (*) p < 0.05 as compared to infected animals receiving ceftriaxone and placebo.

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