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Figure 7 | Journal of Neuroinflammation

Figure 7

From: Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures

Figure 7

C16 prevented activation of caspase-3. Representative blots show the immunoreactivity of procaspase-3, cleaved caspase-3 fragments and tubulin in astrocyte/neuron/microglia co-cultures pretreated with 210 nM of C16 compared to vehicle treatment and with or without 20 μM Aβ42 exposure for 72 h. Data of cleaved-caspase-3 are reported relative to data of corresponding procaspase-3. Results are expressed as percentage of DMSO condition (set at 100%) and are mean ± SEM for 4 experiments in duplicate. ##p < 0.01 and ***p < 0.001, compared to respective controls without C16 by one-way ANOVA with Newman-Keuls multiple comparison test.

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Journal of Neuroinflammation

ISSN: 1742-2094