Figure 4

Genetic deletion of MIF does not affect the cerebral up-regulation of IL-12 and mKC 48 h after tMCAo, in mice. A) Schematic representation of the regions dissected from brains collected 48 h after surgery (sham and tMCAo): infarct core (IC, white) and non-infarct region (within dotted line). Scale bar: 3mm. B and D) IL-12 and mKC protein levels in the cerebral IC and non-infarct region (NIR) of WT and MIF-KO subjected to sham-operation or tMCAo. D and E) IL-12 and mKC protein levels in the serum of WT and MIF-KO 48 h and 7 days after sham-operation or tMCAo. In B, C, D and E we present individual data points and the mean (dash). # p < 0.05 tMCAo IC versus Sham IC (for each genotype). § p < 0.05 tMCAo NIR versus Sham NIR (for each genotype).