Figure 1

IFNβ is far less toxic to OPCs than IFNγ. Phase-contrast images (A-C) and immunocytochemistry for A2B5 (D-F) of rat OPCs treated with GM alone (A, D), GM plus IFNβ (1 kU/ml) (B, E) or GM plus IFNγ (100 ng/ml) (C, F) for 48 h. G, Viability of OPCs cultured with GM (control), GM supplemented with IFNβ (IFNβ), IFNγ (IFNγ), or both (IFNγ + IFNβ) was measured by MTT assay at 48 h after treatment. ** Indicates p < 0.01 compared with control. ** Indicates p < 0.01 compared with control or in comparison between the two groups indicated.