Figure 2
From: Increased local concentration of complement C5a contributes to incisional pain in mice
Pre-treatment with PMX53 (3 mg/kg) abolished the heat hyperalgesia (A) and mechanical allodynia (B) induced by intraplantar injection of recombinant mouse C5a (200 ng). Values are expressed as mean ± SEM, *, P < 0.05, **, P < 0.01 or ***, P < 0.001 (comparison of C5a group and saline group); #, P < 0.05 (comparison of PMX53 group and saline group); ⋆⋆, P < 0.01 and ⋆⋆⋆, P < 0.001 (comparison of PMX53 and C5a groups). An arrow head at time = 0 indicates C5aR agonist injection.