Figure 9

Effects of C5a on mechanical responses of mechanosensitive C- and A-fibers in incised tissue. (A) Example recordings of C-fibers with receptive fields ≤ 2 mm from the incision before and after application of PBS-vehicle or C5a 1 μg/ml. (B-G) Mechanical thresholds (left panels) and stimulus response function (right panels) of C-fibers before and after exposure to PBS-vehicle or C5a 1 μg/ml which have receptive fields ≤ 2 mm (D and E) and > 2 mm (F and G) from the incision and in sham group (B and C). (H and I) Mechanical thresholds (left panels) and stimulus response function (right panels) of A-fibers before and after exposure to PBS-vehicle or C5a 1 μg/ml which have receptive fields ≤ 2 mm from the incision. In left panels, each line represents a single unit, and the small horizontal lines in each graph indicate median values. In right panels, data are presented as means ± SEM.